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KMID : 0828520130170030134
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Journal of the Korean Geriatrics Society
2013 Volume.17 No. 3 p.134 ~ p.137
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Adalimumab Induced Acute Exacerbation of Rheumatoid Arthritis Related Interstitial lung disease
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Park Woo-Kyung
Lee Yeon-Sun
Won Sam
Kim Hye-Reen
Lee Jeong-Hun
Lee Kwang-Bok
Kim Jong-Hyun
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Abstract
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A 69-year-old woman with 6 year history of seropositive rheumatoid arthritis (RA) and asymptomatic interstitial lung disease (ILD) began taking adalimumab for ongoing arthritis despite taking sulfasalazine and hydroxychloroquine for treatment. ILD progressed noticeably after 10 weeks of starting adalimumab. We discontinued adalimumab and added methylprednisolone 40mg, and the patient`s clinical findings gradually improved. The beneficial and adverse effect of tumor necrosis factor-α (TNF-α) inhibitors on RA associated ILD is unclear but this case reports adalimumab could abruptly exacerbate known ILD. We emphasize caution on the use of adalimumab, one of TNF-α inhibitors, in elderly RA patients with preexisting ILD.
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KEYWORD
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adalimumab, rheumatoid arthritis, interstitial lung disease
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